The Jessner's peel is very beneficial for patients with acne, oily, or thicker skin, because it tends to decrease oil production and open clogged sebaceous follicles. It also contributes to the healing process of acne.

The Jessner's peel combines resorcinol, lactic acid, and salicylic acid to result in deeper penetration and greater exfoliation of the outer layers of skin cells. This deeper exfoliation produces noticeable flaking and exfoliation in the following three to four days after the peel, and within a week a smoother, healthier layer of skin will be revealed.